Jason:
I agree with the above suggestions regarding a shotgun as a primary home-defense weapon. There are any number of excellent choices available. I prefer a tactical shotgun rather than a sporting model for the purpose of home defense and, of the various types available, find a pump action to be most suitable. (The mere sound of the slide of one of those "boomers" being racked in a dark room can be rather intimidating in and of itself.) Hang a tac light and laser sight on it and you're good to go.
To Yankee's list of great weapons coming out of Israel, I would add only the Timber Wolf pump carbine chambered in either .357 Magnum or .44 Magnum. They are no longer in production but still show up occasionally in like-new condition on the auction sites.